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Understand why your nose remains stuffy, explore other causes, and find lasting relief strategies. Feb 26, 2025a stuffy nose despite taking allergy medicine can be caused by various factors, including high pollen and mold levels, sinusitis, non-allergic rhinitis, and resistance to the medication. The best medicine for a stuffy nose depends on the cause.

A blocked nose is inflammation inside your nose caused by infections, allergies, or pollution. Key takeaways sinus congestion, also known as a “stuffy nose,” may be caused by allergies or infections like the flu or common cold. Sep 6, 2025there are many natural home remedies for a stuffy nose, but the right method for you may depend on the underlying cause of your congestion.